This paper will analyze anti-Chinese attitudes in Vladivostok and Singapore from the late-nineteenth to the early-twentieth centuries. By focusing on hygiene, one of the most prevalent issues of Sinophobic sentiments, the translocal approach aims to identify similarities and differences in discrimination strategies against the Chinese diaspora and their relation to anti-Chinese narratives. The two Pacific port cities appear to be particularly suitable cases for a contrasting study of local variations of stigmatization against one particular ethnic group in an urban setting: Emigration from southern China to Southeast Asia and from northern China to the Russian Far East bear striking similarities, particularly in terms of timing and patterns of migration, the role Chinese played in certain labor-intensive areas of employment and the organization of ethnic community life. These common qualities had consequences for perceptions of their inhabitants. The racial branding of immigrant ghettos as locations of the “yellow peril” was closely related to the spatial concentration and segregation of the Chinese population. Formal and informal efforts to monitor and marginalize the Chinese in these quarters produced Chinatowns which quickly came to be seen as physical evidence of immutable racial characteristics: moral vice, contagion, disease, and pollution. Yet, as this paper will argue, despite such striking similarities, discourses and strategies were inherently diverse, multi-layered and contradictory.