The majority of Crohn's disease patients will undergo a surgical resection for a complication at some point in their lifetime. A surgical resection treats the complication but is not a cure and Crohn's disease recurrence is common. The goal of postoperative Crohn’s disease management is to prevent recurrence and avoid future surgery. Medications that may be effective at preventing postoperative recurrence include immunomodulators, anti-tumor necrosis factor agents, and antibiotics. Certain risk factors, such as recurrent surgery and penetrating disease, for postoperative Crohn’s disease recurrence may influence management decisions.