Asthma is a chronic inflammatory airway disease that affect over 234 million people worldwide. 6-gingerol, a bioactive component of Zingiber officinale have been reported to possess several pharmacological activities. However, there is a dearth of information on the effect of 6-Gingerol on asthma. This study investigated the effect of 6-Gingerol on mouse model of house dust mite (HDM)-induced asthma. Fifty Balb/c male mice (17±1g) were assigned into 5 groups of 10 animals each. Group 1 and 2 received normal saline and 6-Gingerol (50mg/kg) orally for 8 weeks. Groups 3 was intranasally administered house dust mite (HDM) (25μg in 10μl of saline) for 5days/week for up to 7 consecutive weeks. Group 4 and 5 were administered 6-Gingerol (50mg/kg) and dexamethasone (1mg/kg)1 hour prior to intranasally administered HDM (25μg in 10μl of saline) for 5days/week for up to 8 consecutive weeks. Serum IgE and neutrophils, eosinophils, lymphocyte, macrophages, IL-6, TNF-α, IL-7, Eotaxin and chemokine (C-X-C motif) ligand 1 was determined by in BALF by ELISA. Data were analyzed using ANOVA at α0.05.. 6-Gingerol significantly decreased HDM-induced increase in IgE, neutrophils, eosinophils, lymphocyte, macrophages, IL-6, TNF-α, IL-7, Eotaxin and CXCL-1 when compared with HDM-induced mice. Additionally, 6-gingerol markedly reduced total collagen content, peribronchial inflammation infiltrates, subepithelial collagen deposition and goblet cell hyperplasia in lung tissues of HDM-induced mice. In conclusion, 6-Gingerol elicited a protective effect on HDM-induced asthma in mice via anti-inflammatory properties and attenuation of airway remodeling.