Presentation Authors: Begoña Etcheverry Giadrosich*, Maria Fiol Riera, Lluis Riera Canals, Jaime Fernandez-Concha Schwalb, Xavier Bonet Punti, Jose Francisco Suarez Novo, Oriol Bestard Matamoros, Francesc Vigues Julia, Barcelona, Spain
Introduction: During the past decade, kidneys from controlled donor after circulatory death (cDCD) have significantly raised, in order to increase the number of donors. It achieved 26% of total Kidneys transplant during the last year in Spain. Moreover, some of those kidneys come from older donors. The aim of this study is to evaluate cDCD kidneys obtained from more than 70 years old compared from less than 70 years old.
Methods: We perform a case control study for cDCD kidneys transplanted in one single institution, Hospital Universitari de Bellvitge, Barcelona. We compared kidneys of both < 70 years old and â‰¥ 70 years old.
Results: From August 2013 to March 2018, 126 kidneys transplants from cDCD donors were performed. We compared 2 groups: < 70 years old versus >70 years old (table 1).From logistic regression model, older and diabetic donors are both risk factors for DGF, OR 6.2 (CI95% 1.8-21.1, p=0.004) and OR 7.2(CI95%: 1.6-31.4, p=0.009) respectively. In other hand, NECMO retrieval and hypothermic machine perfusion preservation seems to be a protective factor for DGF, OR 0.17 (CI95% 0.04-0.71, p=0.015) and OR 0.21 (CI95% 0.07-0.74, p=0.014) respectively. The logistic regression model shows AUC of 0.81 (CI95%: 0.72- 0.88). Kaplan- Meier Survival curve shows a 0.90 survival (CI95%: 0.73-0.97) at 43.83 month for older kidneys. Log-rank Survival analysis shows no difference between two groups (p=0.899).
Conclusions: Older and diabetic donor (â‰¥ 70 years old) is a risk factor for DGF. Instead, NECMO and HMP preservation donors are protective factors for DGF in cDCD kidneys. Nevertheless, there is no difference in admission length, and kidney survival between groups. Those are interesting observations in order to increase the number of donors.