Presentation Authors: Mohamed Ray-Zack, Preston Kerr*, Yong Shan, Jacques Baillargeon, Yong-Fang Kuo, Hemalkumar Mehta, Stephen Williams, Galveston, TX
Introduction: Exposure to benzene and aromatic amines are risk factors for bladder cancer.Incidence rates according to proximity to oil refineries are largely unknown. We sought to determine proximity of oil refineries and bladder cancer incidence in the State of Texas, which is home to the largest number of oil refineries in the United States.
Methods: We used the Texas Cancer Registry database to identify patients diagnosed with bladder cancer from January 1, 2001 to December 31, 2014. The U.S. census data from 2010 was used to ascertain overall population size, age and sex distributions. Heat maps of the 28 active oil refineries in Texas were developed. Incidence of bladder cancer were compared according to proximity ( < 10 vs. â‰¥10 miles) to an oil refinery. Risk ratios (RR) were adjusted using a Poisson regression model.
Results: Results: A total of 45,517 incident bladder cancer cases were identified, of which 5,501 cases were within 10 miles of an oil refinery. In adjusted analyses, bladder cancer risk was significantly greater among males vs. females (RR 3.41, 95% Confidence Interval (CI), 3.33-3.50), and greater among people living within 10 miles from an oil refinery than those living outside a 10-mile radius from an oil refinery (RR 1.19, 95% CI, 1.08-1.31). A heat map demonstrates the locations of oil refineries and the varying incidences of bladder cancer at Texas ZIP codes (Figure 1).
Conclusions: People living within 10 miles from oil refineries were at greater risk for bladder cancer. Further research into exposure to oil refineries and bladder cancer incidence is warranted.
Source of Funding: This study was conducted with the support of a Department of Defense Peer Reviewed Cancer Research Program (PRCRP) Career Development Award (W81XWH1710576) and the Herzog Foundation (SBW). This study was supported by a Center for Translational Science Award by the NIH (TL1TR001440 and UL1TR001439) (MDR).