Presentation Authors: Vivek Venkatramani*, Maria Becerra, Miami , FL, Isildinha Reis, Miami, FL, Nachiketh Soodana-Prakash, Miami , FL, Erik Castle, Phoenix, AZ, Mark Gonzalgo, Miami , FL, Michael Woods, Chapel Hill, NC, Robert Svatek, San Antonio, TX, Alon Weizer, Ann Arbor, MI, Badrinath Konety, Minneapolis, MN, Mathew Tollefson, Phoenix, AZ, Tracey Krupski, Charlottesville, VA, Norm Smith, Chicago, IL, Ahmad Shabsigh, Columbus, OH, Daniel Berocas, Nashville, TN, Marcus Quek, Maywood, IL, Atreya Dash, Seattle, WA, Adam Kibel, Boston, MA, Raj Pruthi, Chapel Hill, NC, Jeffrey Montgomery, Ann Arbor, MI, Chrostopher Weight, Minneapolis, MN, David Sharp, Columbus, OH, Sam Chang, Nashville, TN, Michael Cookson, Norman, OK, Gopal Gupta, Alex Gorbonos, Maywood, IL, Edward Uchio, Irvine, CA, Eila Skinner, Stanford, CA, Kerri kendrick, San Antonio, TX, Joseph Smith, Nashville, TN, Ian Thompson, San Antonio, TX, Dipen Parekh, Miami , FL
Introduction: Health-related quality of life (HRQoL) can be significantly affected following radical cystectomy (RC) and factors affecting it have not been well studied in this population. We evaluated predictors of QOL 3 months following RC in patients from the RAZOR trial; a multicenter, open-label non-inferiority phase III randomized trial comparing robot-assisted radical cystectomy (RARC) to open cystectomy (OC).
Methods: HRQoL was evaluated using the Functional Assessment of Cancer Therapy-Vanderbilt Cystectomy Index (FACT-VCI). All questionnaires were administered at baseline, 3- and 6- months (mo) postoperatively. A 3-mo postoperative time interval was chosen for this analysis. QOL comparisons between RARC and OC have been reported previously. Multiple regression analysis was conducted adjusting for key covariates to identify factors predicting FACT-VCI total score at 3-mo.
Results: BMI â‰¥30 [Î²estimate -10.80 (-20.03, -1.57), p=0.022] and worsening of independent activities of daily living (iADL) [Î² estimate -2.27 (-4.18, -0.36), p=0.021] at 3 months were associated with lower QOL (Table 1). Increasing age was associated with higher QOL [Î² estimate 0.49 (0.05, 0.94), p=0.031]. Surgical approach (RARC or OC), type of diversion, perioperative chemotherapy and major complications were not predictive of QOL at 3-mo.
Conclusions: Postoperative HRQoL was not significantly affected by surgical approach, type of diversion, chemotherapy and major complications. However, age, BMI and iADL impacted QOL significantly. This provides important prospective data for patient counseling and reiterates the importance of studying QOL after major surgical procedures to reach a better understanding of how it can be affected, and potentially improved.
Source of Funding: The RAZOR trial was supported by the National Institutes of Health (NIH) National Cancer Institute (NCI; grant number 5RO1CA155388).