Presentation Authors: Mahmoud Mima*, Whitney R Halgrimson, Chicago, IL, Stephen J Freedland, Los Angeles, CA, Gerald L Andriole, St. Louis, MO, Samuel J Ohlander, Daniel M Moreira, Chicago, IL
Introduction: Impaired sexual function is observed with chronic and persistent alcohol consumption. We sought to assess the association between quantitative alcohol consumption per week and baseline sexual function among men in the Reduction by Dutasteride in Prostate Cancer Events (REDUCE) study.
Methods: We analyzed data of 6,754 men aged 50 to 75 years in the REDUCE study. Men were divided into four groups based on self-reported weekly alcohol consumption. Sexual function variables analyzed were: serum total testosterone and self-reported questionnaires including sexual activity, erectile dysfunction, libido, and Problem Assessment Scale of Sexual Function Index (PAS-SFI). Baseline demographics and comorbidities were compared using chi-square test and analysis of variance. Differences in sexual function between groups were assessed by univariate and multivariate analyses.
Results: A total of 1,787 (26.5%) had 0 drink/week, 2,516 (37.2%) consumed 1-5 drinks/week, 1,204 (17.8%) consumed 6-10 drinks/week, and 1,247 (18.5%) consumed more than 10 drinks/week. Age and body mass index were similar between cohorts while race and the prevalence of diabetes, coronary artery disease, hypertension, and dyslipidemia varied significantly across groups (all P < 0.05). Although uni- and multivariate regression analyses revealed a negative correlation between alcohol consumption and total testosterone level (P < 0.01), alcohol consumption was associated with improved sexual function measured by PAS-SFI questionnaire (P < 0.05). Alcohol intake was not, however, associated with sexual activity, erectile dysfunction, or decreased libido when assessed separately in either uni- or multivariable analyses.
Conclusions: Among men in the REDUCE study, alcohol consumption was associated with lower total testosterone level but improved overall sexual function, while no correlation was found when each sexual function component was assessed separately. Further studies to explore these relationships would be valuable to clinicians and their patients, especially those with hypogonadism.