Presentation Authors: VIPIN TYAGI*, SUDHIR CHADHA, NEW DELHI, India
Introduction: In India every year 200000 new patients are in need of kidney transplantation but only 10,000 kidney transplant performed in a year. The primary reason is limited availability of the live and cadaveric donors. The most unfortunate are the donors who willing to donate but could not because of the incompatible blood group. In order to increase the donor pool the concept of ABO incompatible kidney transplant came into the system. We here present our single center experience of ABO incompatible kidney transplants.
Methods: Since 2012 we have perfomed 1300 kidney transplant, out of which 166 transplants were across the blood group. Preexisting antibodies were evaluated in the recipient blood and once found acceptable, the process of removal of antibodies were started followed by IVIG, Rituximab and ATG. The kidney transplant was then carried out. The demographic parameters of the pair were evaluated, all preoperative parameters , intraoperative parameters and postoperative surgical and nephrological parameters were recorded and evaluated.
Results: The mean age of recipients was 41.6 years (32-58), mean age of donors was 40.17 yrs(28-62), wife was the most common donor , Recipient Blood Group was most commonly O and the donors has B blood group most commonly.Overall patient survival was 95% , graft survival 92%(110/121) with a rejection in 34 patients . Post op complications were noted in 38.7% of which includes septicemia UTI, ATN, thrombocytopenia and prolonged prothrombin time
Conclusions: This study shows that ABO incompatible renal transplants have acceptable long term patient and graft survival, Desensitization protocol is simple but increases the cost of therapy.