Presentation Authors: mohankumar vijayakumar*, sudharshan balaji, Abhishek Singh, Arvind Ganpule, Ravindra Sabnis, Mahesh Desai, nadiad, India
Introduction: In kidney transplantation, preservation has a significant influence on organ function. histidine-tryptophan-ketoglutarate (HTK) solution has gained wide spread acceptance in recent times as a preferred solution for renal transplantation especially in cadaver organ transplantation where the ischemia time is more. We conducted a study to compare the effect of our indigenous solution with HTK for live renal transplantation
Methods: Prospective, randomized study conducted from July 2017 to October 2017. All patients who underwent live allograft renal transplantation were included.The exclusion criteria were re transplant ABO incompatable transplant and multiple vessels, After informed consent patients were randomized to two groups using computer generated block randomization. Patients in group I received our indigenous solution which as prepared by injecting 40 meq of KCL and 1000 units of unfractionated heparin in 500 ml of normal saline while patients in group II received HTK.
Results: Forty patients were randomized into two groups of twenty each. Both the groups were comparable in terms of demographic data such as age, sex, duration of CKD, co morbidities, Ischemia time. There was no statistically significant difference between the two groups in terms of the above parameters. The patient and graft survival was also the same in both the groups. The graft function at one month was significantly lower in the indigenous solution group compared to HTK group. However at end of 6 months there is no difference between the graft function, survival and patient survival between the two groups.
Conclusions: The indigenous solution based on normal saline is equally efficacious as HTK solution in case of live renal transplantation