Presentation Authors: Ayodeji Sotimehin*, Bruce Trock, Baltimore, MD, Uzoma Anele, Richmond, VA, Wendy Madden, Belinda Morrison, Kingston, Jamaica, Arthur Burnett, Baltimore, MD
Introduction: Little is known about the long-term consequences of recurrent priapism on erectile function, penile deformity, and mental health. The Priapism Impact Profile (PIP) is a 12-item instrument used to measure three key domains presumed to be worsened by priapism: quality-of-life (QoL), sexual function (SF), and physical wellness (PW) and has been previously validated in adults with priapism. In this study, we evaluated the validity and reliability of PIP in a Jamaican cohort of sickle cell disease (SCD) patients experiencing priapism.
Methods: 100 SCD patients with a history of priapism were recruited from a sickle cell clinic in Kingston, Jamaica and administered the PIP questionnaire. Patients then rated each item of the PIP for clarity and importance. 20 of the 100 patients repeated the PIP questionnaire within 1 year of initial testing. Statistical testing was employed to evaluate the validity and reliability of PIP.
Results: Patients were divided into active priapism (54) and remission (46) groups based on whether they experienced a priapism episode within the past year. Patients in the active priapism group were older (p < 0.05), had a shorter duration of disease (p < 0.05), and had more frequent priapism episodes (p < 0.05) than the remission group. The active priapism group had higher total PIP score and worse QoL, SF, and PW scores than the remission group (p < 0.05 for all). The item-total Cronbachâ€™s Î± reliability coefficient for the PIP score was 0.78. Individual PIP domains had Î± coefficients of 0.77 for QoL, 0.78 for SF, and 0.81 for PW. These values are consistent with a good (r > 0.70) item domain/total instrument interrelatedness. Questions were rated as having medium or high clarity and importance by an average of 82% and 69% of patients, respectively.
Conclusions: The PIP questionnaire was successfully validated in a cohort of SCD patients and adequately discriminated patients with active priapism from those in remission.