Presentation Authors: Nir Tomer*, New York , NY, Khawaja Bilal, Elie Kaplan-Marans, Juan Fulla, Michael Palese, New York, NY
Introduction: Donor nephrectomy (DN) is a procedure performed in order to provide recipients with a new kidney to treat end stage renal disease due to a variety of pathologies. The following analysis evaluated the incidence of depression diagnosis in DN patients and potential factors that may influence this diagnosis.
Methods: DN patients between 2006-2010 were identified from the Statewide Planning and Research Cooperative System (SPARCS) database. Donors were tracked for depression incidence 5 years prior to DN and 5 years post-DN. 2006-2010 was chosen since the upper limit of tracking the patients in the database is 2015. Patients with unknown or missing demographic information were excluded from analysis. A chi-square test was used to compare variables. Multivariable logistic regression was used to determine independent predictors of postoperative depression diagnosis.
Results: 4727 DN cases were obtained for analysis. The pre-DN 5-year incidence of depression was 9.2%. The post-DN 5-year incidence of depression was 13.3%. Additionally, yearly incidence rates post-DN increase compared to pre-DN (figure 1). Multivariable logistic regression identified one key variable that was significantly predictive of post-DN depression: prior depression diagnosis (OR=9.308, CI:7.465-11.606, p < 0.001). All other significant variables that influence post-DN depression are reported in table 1.
Conclusions: The present study indicates that DN increases the incidence of depression in donors and suggests that DN may precipitate depression. The key predictor of depression following DN was a prior depression diagnosis. This information may be helpful in identifying patients at high risk for developing depression following DN. This can help physicians deploy the necessary resources for postoperative care in high-risk donors as well as better inform future donors about the risks associated with DN.