Presentation Authors: MEHMET MURAD BASAR*, İSTANBUL, Turkey, HAKAN YELKE, ISTANBUL, Turkey, SERKAN SELIMOGLU, İSTANBUL, Turkey, EMRE SOYSAL, ISTANBUL, Turkey, YESIM KUMTEPE-COLAKOGLU, SEMRA KAHRAMAN, İSTANBUL, Turkey
Introduction: Microfludic sperm sorting is a new method of sperm selection for ART procedures. The aim of the study was to evaluate the efficacy of this method for sperm sorting in infertile cases which had a repeated implantation failure history, and compared their fertilization rate to control cases.
Methods: A total of 45 patients having repeated implantation failure previously enrolled into the study. The patients were evaluated with a detailed medical history and a comprehensive physical examination, all probable risk factors were recorded. Semen analysis was assessed according to WHO 2010 guideline. Sixty infertile cases in the same age to whom ART procedure applied were selected as control group. Additionally, microfludic system used cases were divided into two groups according to different systems performed for sperm sorting: Group-I: Fertile and Group-II: Fertile Ultimate. Patientsâ€™ age, sperm parameters, and embryologic data were compared between two groups by using Student-t, Mann-Whitney U and Pearson Ï‡2 tests.
Results: Patients and control group data were given in table-1. We have not observed statistical difference regarding compared parameters between microchip and control group. Additionally, no statistical difference was found between two groups according to overall fertilization rate (69.6% vs. 74.6%; Pearson Ï‡2=0.397, p=0.529). Then, same parameters were compared between two different microchip systems. Patientsâ€™ data were given in table-2. Although some parameters were statistically higher in group-1 than group-2, there were no statistical difference between two different sorting systems according to over-all fertilization rate (63.9% vs 66.3%; Pearson Ï‡2=0.088, p=0.787).
Conclusions: While microfluidic sperm sorting system is a new method for sperm selection in IVF laboratory unit, there is not enough data about the clinical outcome. We need further studies about their clinical efficacy.