Presentation Authors: Angelo Territo*, Jose Daniel Subiela, Barcelona, Spain, Gerit Theil, Halle, Germany, Lluis Gausa, Giuseppe Basile, Federica Regis, Barcelona, Spain, Romain Boissier, Marseille, France, Mohammed Nasreldin, Halle, Germany, Andrea Gallioli, Barcelona, Spain, Paolo Fornara, Halle, Germany, Lluis Guirado, Alberto Breda, Barcelona, Spain
Introduction: Open kidney transplantation (OKT) is the preferred approach in kidney transplantation (KT), but robot-assisted kidney transplantation (RAKT) has been recently standardized. The main aim of this study is to prospectively quantify the inflammatory response and the functional results of OKT vs RAKT.
Methods: We prospectively compared the inflammatory response between standard OKT and RAKT. 30 patients underwent pre-emptive KT between January and December 2017 (15 RAKT, 15 OKT). Blood levels of inflammatory markers (NGAL, CRP, IL-6) were measured at several time points: T0 (preoperative/baseline), T1(H1), T2(H6), T3(H12), T4(H24), T5(D2), T6(D3) and T7(D5) after KT. Serum creatinine and estimated glomerular filtration rate (eGFR) were evaluated at postoperative days 1, 3 and 7. A point-to-point analysis was performed, the differences in clinical variables between RAKT and OKT were evaluated using the unpaired t-test or non parametric Mann Whitney U test.
Results: IL-6 and CRP significantly increased in both groups after surgery compared with baseline (Ã—9 and Ã—15 respectively, all p < 0.01). There was a significant difference in the mean level of IL-6 at T1 (H1) and T3(H12) in the advantage of RAKT (p < 0.01). Significant differences in the mean level of CPR were found at T3(H12) and T5(D2) in the advantage of RAKT (p < 0.01). Compared to baseline NGAL significantly decreased in both RAKT (p < 0.01) and OKT (p < 0.01). Significant differences in the mean level of NGAL were found at T3(H12), T4(H24) and T6(D3) in the advantage of RAKT. Serum creatinine and eGFR at postoperative days 1, 3 and 7 were similar in RAKT and OKT (all p>0.05).
Conclusions: RAKT trended to induce a lower inflammatory response compared with OKT. Short term functional outcomes and complications rate were similar in RAKT vs OKT.
Source of Funding: The project has been supported by the Eureopean association of Urology (EAU). The EAU Section of Transplantation Urology (ESTU) has sponsored a grant.