Presentation Authors: Dmitry Pushkar, Nika Akhvlediani*, Alexander Bernikov, Igor Reva, Moscow, Russian Federation
Introduction: Among all patients with azoospermia, 15-20% of them are obstructive azoospermia. Optimization of the treatment&[prime]s results mostly consists in the surgical technique improvement. In this study, the effect of follicle-stimulating hormone (FSH) therapy on the viability of micro-anastomoses after the reconstruction of the seminal paths was studied.
Methods: 68 patients with epididymal obstructive azoospermia were randomly divided into 2 groups. Group 1 patients (n=33) did not receive any treatment after longitudinal intussusception vasoepididymostomy (LIVE). Patients of group 2 (n=34) after a LIVE for 3 months were treated with FSH at a dose of 150 IU subcutaneously 3 times a week. After 3 and 6 months after surgery, the patient&[prime]s semen were examined.
Results: In the first group, at 3 and 6 months after vasoepididymostomy, the patency was noted in 24 (72.7%) and 20 (60.6%) cases, respectively (p=0.046). In the second group, within a specified time frame, the patency of micro-anastomoses was ascertained in 30 (88.2%) and 29 (85.3%) cases, respectively (p=0.092). Intergroup comparison of results after 3 and 6 months after LIVE showed a significant difference (p=0.038 and p=0.021).
Conclusions: FSH-therapy for 3 months after vasoepididymostomy allows obtaining significantly higher and stable rates of the patency of micro-anastomoses.