Presentation Authors: Wenjun Xiao*, Yao Zhu, Dingwei Ye, Yuanyuan Qu, Jun Wang, Shanghai, China, People's Republic of
Introduction: Adrenal neuroblastoma (NB) is a common child malignancy that originates in the adrenal cortex. It is rare in adult. However there are also cases diagnosed or surviving in adult. Besides, disease prognosis is not constant over time, and the conditional survival (CS) of patients with NB needs to be evaluated.
Methods: The SEER database was queried for patients diagnosed with adrenal neuroblastoma. The cases aging â‰¥14 years old at diagnosis or surviving over 14 years old were selected. Clinical and pathologic information were collected as well as survival status as of December 31, 2014. Cases with unavailable follow-up information were excluded. CS was defined as the probability of surviving for an additional period on the condition that a patient had already survived for a designated length of time.Survival analysis were performed. CS(y/x), is the probability of surviving an additional y years, S(x+y), given that the patient has already survived x years S(x): CS(y/x)=S(x+y)/S(x).
Results: A total of 454 patients were selected, and 55 cases aged â‰¥14 years old at diagnosis while 399 cases survived over 14 years old. The gender ratio was 1.2 male to 1 female, and the number of left and right proportion was 1.5:1. Factors associated with higher overall mortality were older age at diagnosis and diagnosed with distant metastases. Age at diagnosis was the most important prognostic factors. Patients diagnosed at age of â‰¥14 years old had the median disease-specific survival (DSS) of 117 months. In the subgroup surviving over 14 years old, patients diagnosed at age of >5 years had a 5-year conditional DSS rate of 71.2% at the time point of 14 years old, which was significantly less than that of patients diagnosed at age of â‰¤5 years old (99.7%). So we further compared the subgroup aging from 5 to 14 years at diagnosis and surviving over 14 years old (Figure a blue) with the subgroup aging â‰¥14 years at diagnosis (Figure a red). The gains in 5-year conditional DSS over time were more pronounced in patients with older age at diagnosis, resulting in the decrease of the differences of conditional DSS between the different groups (Figure b).
Conclusions: These findings provided a new perspective for understanding the prognosis of adrenal NB. The age at diagnosis play a very important role even for the patients surviving over 14 years old.