Presentation Authors: Cosimo De Nunzio*, Rome, Italy, Antonio Luigi Pastore, Latina, Italy, Riccardo Lombardo, Antonio Nacchia, Rome, Italy, Antonio Carbone, Andrea Fuschi, Latina, Italy, Lorenzo Dutto, Glasgow, United Kingdom, Andrea Tubaro, Rome, Italy, Jöern H. Witt, Gronau, Germany
Introduction: Recent evidence suggested the importance of preoperative patients â€™quality of life on post-operative functional and oncological outcomes. The aim of our study was to evaluate the impact of preoperative quality of life on post radical prostatectomy overall survival.
Methods: Between 2012 and 2017, all patients undergoing robotic radical prostatectomy (RRP) for prostate cancer were enrolled. Demographic, clinical and histological characteristics of the patients were recorded. Preoperative quality of life was evaluated with the EORTC QLQ-C30 including the Global Health score (GHS). Cox regression was used to evaluate the role of GHS as a predictor of patients â€˜overall survival.
Results: Overall 7606 patients were enrolled. Median age was 65 (IQR: 60/70) years, median BMI was 26.6 (IQR:25/29) kg/m2, median PSA was 7 (IQR:6/11) ng/ml and median prostate volume was 37 (IQR:28/52) ml. Overall 1911/7606 patients presented high grade disease on prostate biopsy and 1521/7606 (20%) presented advanced clinical stage. 193 patients died (2.5%) during a median follow-up of 36 months (IQR: 12/60). On multivariate analysis age, biopsy prognostic grade group (PGG), ASA score and EORTC-Global Health Score were the only preoperative predictors of overall survival
Conclusions: In our study a comprehensive evaluation of pre-operative patientsâ€™ quality of life, assessed by the EORTC QLQ-C30 questionnaire, and comorbidities can predict the long-term survival in patients treated with robotic radical prostatectomy. Although further studies should confirm our results, we firstly showed the importance to assess patients â€˜quality of life before radical prostate surgery.