Presentation Authors: Joon Chae Na*, Min-Gee Yoon, Lee Dongu, Seoul, Korea, Republic of, Hyung Ho Lee, Goyang, Korea, Republic of, Young Eun Yoon, Kwang Hyun Kim, Woong Kyu Han, Seoul, Korea, Republic of
Introduction: There is currently a trend to expand the criteria for kidney donation to meet the increasing demand. Many transplantation centers are confronted to evaluate â€œmedically complex donorsâ€. Candidates occasionally present with microproteinuria on predonation examination. While a protein excretion rate(PER) < 150mg/day is considered safe, there is no clear guideline for accepting donors with microproteinuria: a PER in the range of 150~500mg/day. Thus we aimed to evaluate the functional outcome of donors with microproteinuria.
Methods: Donors with a preoperative 24hr PER result and a follow up of more than 3 years were included in the study. The study period was from March, 2006 to Feb, 2014. The annual change of estimated GFR from 1 to 5 year after donation was studied.
Results: A total of 825 donors were included in the study. 787 donors had normal PER ( < 150mg/day, control group) and 38 had microproteinuria (PER 150~500mg/day, mPr group). The baseline characteristics of the two groups were not significantly different. (Table 1) Multivariate linear regression analysis of the eGFR after 1 year post-donation was evaluated and predonation microproteinuria was not a significant predictor. (Table 2) Linear mixed model analysis was performed to fix random effect by patients, and the eGFR change across time was not significantly different. (p=0.111, Table 3)
Conclusions: Living kidney donors with microproteinuria before donation are not at increased risk of renal function deterioration and have similar functional outcome compared to donors free from microproteinuria.