University Hospitals Cleveland Medical Center
Adonis Hijaz, MD is a Professor of Urology at Case Western Reserve University and Director of Center of Female Pelvic Medicine and Surgery at University Hospitals Cleveland Medical Center. He is a surgeon-scientist with prior peer reviewed funding to study the diseases of lower urinary tract. He has participated in creation of several innovative animal models of lower urinary tract dysfunction and currently pursuing projects to understand the mechanisms mediating the balance between injury and recovery following birth trauma. Through NIDDK funded K-08 award, he have been successful in building collaborations between CWRU Urology and the departments of Biomedical Engineering, Mechanical Engineering, Biology, and Imaging/Radiology at CWRU. These collaborations have included exploration of both the efficacy of stem cell therapy in animal models of lower urinary tract dysfunction as well as in vivo tracking of stem cells in rodent models.
Over the past 10 years, his research reproducibly demonstrated over-expression of stem cell homing molecules in the injury model. More recently his team demonstrated accelerated recovery of urethral continence following local and systemic injection of bone marrow derived mesenchymal stem cells. Current collaborative work focuses on harnessing the capacity of stem cell chemokines in enhancing the continence recovery in injury models. Moreover, the team is studying the impact of mesenchymal stem cells on the host response to injury.