Presentation Authors: Lael Reinstatler*, Kevin Shee, Lebanon, NH, Kristian Stensland, Burlington, MA, Lawrence Dagrosa, John Seigne, Einar Sverrisson, Lebanon, NH
Introduction: The Human Papilloma Virus (HPV) is a recognized carcinogenic factor. Previous studies have shown a possible association between HPV and bladder cancer, however HPV serology has not been reported. In this study, we assessed the correlation between bladder cancer and HPV positive serology.
Methods: Using NHANES, a large nationally-representative population-based survey, we gathered clinical and demographic data on all patients with a diagnosis of bladder cancer over from 2007-2010 and analyzed their HPV serology status. We assessed the effects of positive serologic results for HPV18, HPV16, HPV11, and HPV6 on the rates of bladder cancer diagnosis.
Results: Over the four-year period there was a weighted population of 155,650,000 Americans. The prevalence of HPV positive serology was as follows: HPV18 â€“ 5.5%, HPV16 â€“ 13.2%, HPV11 â€“ 6.4%, HPV6 â€“ 17.4%. There were 443,948 bladder cancer cases. Among cases there was a higher prevalence of male gender (80% vs 53%, p = 0.0056), Caucasian race (93% vs 66%, p = 0.001), and HPV6 positive serology (18.1% vs 17.6%, p = 0.0005). There was no difference among the other three HPV types. On logistic regression controlling for race, gender, and smoking status, increasing body weight (OR 1.01, p < 0.0001) and HPV6 positivity (OR 1.9, p < 0.0001) were associated with increased odds of bladder cancer diagnosis while HPV11 positivity (OR 0.23, p < 0.0001) was associated with a decreased odds of bladder cancer diagnosis.
Conclusions: Prior research has shown that there is a relationship between HPV and bladder cancer, but this relationship has previously been incompletely defined. In this large, nationally representative database, we describe a significant association of HPV6 positive serology with a diagnosis of bladder cancer. This finding is striking and might affect future investigation into the pathophysiologic basis of this relationship.