Pediatric Cancer

EDU 17 - (INTERACTIVE) Radiation Therapy-Related Cardiac Risk in Childhood Cancer Survivors - Informing Clinical Decisions

9/17/2019
2:45 PM - 4:00 PM
Location: Room W194

Session Type: Education
1.25 AMA PRA Category 1 Credits™
1.25 CAMPEP Credits
1.50 MDCB Credits

Recently (Bates et al. 2018), the CCSS has evaluated the dose-response relationship between cardiac disease and the percent of heart volume receiving = 20 Gy (V20), as well as the percent of volume receiving = 5 Gy with a maximum dose to the heart of 20 Gy) to small cardiac volumes (0.1% - 29.9%) were associated with an elevated risk (RR 2.4, 95% CI 1.4 - 4.2)
(2) Low-moderate doses (5.0-19.9 Gy) to large cardiac volumes (>50% of the heart) were associated with an increased risk (RR 1.6, 95% CI 1.1 - 2.3).

Learning objectives: understand the cardiac dose volume data/risk models and how they can be used in clinical practice.

1. Retrospective Heart Dosimetry for an Epidemiologic Study(Rebecca Howell, PhD, MD Anderson Cancer Center:
a. Discuss the challenges of estimating organ doses for large cohorts
b. Describe common dosimetry methods for organ dose reconstruction
c. Describe how mean doses and dose volume metrics were calculated
d. Describe dosimetric uncertainties and impact on dose response models

2. Therapy-Related Cardiac Risk (James Bates, MD, University of Florida):
a. Present radiation therapy and other treatment related risks
b. Discuss potential clinical implications of dose-volume based risk models and how they may be used to inform (1) current radiation treatment planning to reduce cardiac dose and guide future treatment protocols and (2) clinical practice guidelines for post therapy surveillance and risk-reducing strategies.

3. Perspectives from Pediatric Normal Tissue Effects in the Clinic (Louis Constine, MD, University of Rochester)

Learning Objectives:

Presentations:

Rebecca Howell, PhD

MD Anderson Cancer Center

Disclosure:
Employment
The University of Texas MD Anderson Cancer Center

Biography:
Rebecca M. Howell, PhD, DABR, FAAPM, Assoicate Professor, Department of Radiation Physics, Section of Outreach Physics, The University of Texas MD Anderson Cancer Center. I am the Director of the Late Effects Group. Our research focuses on radiation therapy (RT) -related late effectsI am also the Director of the Radiation Dosimetry Service. We provide validation of dose calibrations, i.e., independent peer review, for RT machines in radiation oncology clinics and for blood in irradiators at blood banks.

Presentation(s):

Send Email for Rebecca Howell


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