Radiation and Cancer Biology

Panel 16 - FLASH-RT: The innovation of ultra-high dose-rate radiotherapy, a transformative collaboration of biology and physics.

9/17/2019
2:45 PM - 4:00 PM
Location: Room W185

Session Type: Panel
1.25 AMA PRA Category 1 Credits™
1.25 CAMPEP Credits
1.5 MDCB Credits

Conventional dose-fractionation evolved to maximize the biological therapeutic ratio and limit the harmful effects of radiotherapy. Likewise, technological advantages improved the precision of radiation delivery to further limit normal tissue damage. The most recent innovations in experimental radiotherapy combined technology innovations with novel radiobiology to advance the delivery of radiotherapy to extreme dose rates of ~50-300 Gy/second, so-called FLASH-RT. Preclinical studies in large animals have demonstrated remarkable sparing of normal tissue toxicities. Clinicopathologic late effects typically seen after conventional dose-rate fractionation were absent after FLASH-RT. These data offer the potential to provide a novel radiotherapy-based treatment. This collaborative session will describe the innovative radiobiology of FLASH-RT and the on-going physics studies that are developing the technology for clinical translation of FLASH-RT.

Learning Objectives:

Presentations:

Brian Marples, PhD

University of Miami

Disclosure:
Employment
University of Miami: Radiobiologist: Employee

Compensation
ASTRO: Editor: Travel Expenses

Leadership
ASTRO: SEPD committee: Member and Chair

Presentation(s):

Send Email for Brian Marples

Marc Mendonca, PhD

Indiana University School of Medicine

Disclosure:
Employment
IU School of Medicine: Professor: Employee

Compensation
Radiation Research Society: Consultant

Leadership
Radiation Research Society: Executive Committee & Council Member: Editor-in-Chief Radiation Research

Biography:
Dr. Marc S. Mendonca is a Professor of Radiation Oncology & Medical and Molecular Genetics, and Director of Radiation and Cancer Biology at Indiana University School of Medicine. Dr. Mendonca is an internationally known researcher with extensive expertise in X-ray and proton radiation biology related to the clinical uses of radiation. Dr. Mendonca’s research investigations are focused on gaining a better understanding of radiation’s ability to both heal and harm. His research can be generally separated into two main areas: 1) Understanding the mechanism of radiation-induced cancer and its prevention by natural antioxidants, and 2) Increasing the effectiveness of radiation as a treatment for lung and pancreatic cancers by biological (alteration of NF-kB activity and Warburg metabolism) and physical approaches (protons, very high energy electrons, and nanoparticles) to improve tumor control and minimize damage to normal tissues. Since 2011 Dr. Mendonca has also served as the Editor-in-Chief of the journal Radiation Research.

Presentation(s):

Send Email for Marc Mendonca


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Panel 16 - FLASH-RT: The innovation of ultra-high dose-rate radiotherapy, a transformative collaboration of biology and physics.



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Send Email for Panel 16 - FLASH-RT: The innovation of ultra-high dose-rate radiotherapy, a transformative collaboration of biology and physics.