Radiation and Cancer Biology

Panel 05 - Liquid Biopsies for Predicting Radiation Response

9/16/2019
10:45 AM - 12:00 PM
Location: Room W184

Session Type: Panel
1.25 AMA PRA Category 1 Credits™
1.25 CAMPEP Credits
1.5 MDCB Credits

Human cancer exhibits extensive genomic and transcriptomic
heterogeneity. Defining and understanding this heterogeneity to
improve treatment efficacy is challenging. Traditionally such
experimental approaches have depended on invasive tumor biopsies
to obtain tumor tissue for genomic analysis. However, less-invasive
liquid biopsies utilizing high-resolution genomic and gene
expression data from state-of-the-art sequencing methodologies
are now becoming common, these methods are more convenient
that invasive biopsies and allow repeat sampling. For example,
tumor cells and circulating tumor DNA is continually released into
the blood and these can be detected and monitored as predictors of
treatment response. Combining such molecular approaches allows a
genomic fingerprint to be obtained to guide clinical practice. This
session will summarize the pre-clinical and clinical research
investigating molecular heterogeneity of cancer cells at the wholecell,
genomic and transcriptomic levels, and describe how tumor
heterogeneity affects tumor aggressiveness and metastasis, with the
aim of providing experimental approaches to improve patient care.

Learning Objectives:

Presentations:

Brian Marples, PhD

University of Miami

Disclosure:
Employment
University of Miami: Radiobiologist: Employee

Compensation
ASTRO: Editor: Travel Expenses

Leadership
ASTRO: SEPD committee: Member and Chair

Presentation(s):

Send Email for Brian Marples

George Wilson, PhD

William Beaumont Hospital

Disclosure:
Employment
Beaumont Health (Department of Radiation Oncology)

Presentation(s):

Send Email for George Wilson


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