Caloric restriction is a dietary intervention known to improve metabolism and to increase longevity in organisms across taxa. CR affects fat metabolism through not well known mechanisms. Emerging data suggest that a crosstalk between the circadian clock and caloric restriction is essential for metabolic benefits and increased longevity. Describe the role of circadian clock and rhythms in the fat metabolism under of calorie restriction.
Caloric restriction reprogramms diurnal rhythms in gene expression. Discuss a a reprogramming of rhtyhms in protein translation by caloric restriction
Discuss how does reprogramming of protein translation provide molecular connection between diet and fat metabolism.