Treadmill training can be utilized to foster the achievement of walking in young children as well as for optimizing walking activity in older children with cerebral palsy (CP) and other neurodevelopmental diagnoses. But what is the optimal intensity, frequency, duration and type of training at different stages? Does one size fit all? This course is designed to explore the differences in treadmill protocols between pre-ambulatory children who are working on walking acquisition and school-aged children who may be experiencing limitations with walking activity and participation. The presenters will explain the underlying conceptual frameworks of neuroplasticity and muscle plasticity that informed their research. The practical application and results of different training protocols will be shown via the presenters’ research on pre-ambulatory and school-aged children with CP and other neurodevelopmental diagnoses.