SESSION REQUIRES ADDITIONAL REGISTRATION ($). The 2019 ACR Clinical Research Conference is focused on clinical research and big data. Large amounts of data aggregated by registries, mobile platforms, social media and electronic health records provide new opportunities for clinical research. The conference will feature thought leaders from the fields of epidemiology, computer science, clinical informatics, public health and medicine to discuss the pitfalls, challenges and also opportunities these new data sources present for rheumatology research. In addition, faculty will highlight effective applications of data analytic methods from biostatistics, machine learning and data mining, while also reviewing approaches to limit potential biases from different data sources.