Annual Scientific Meeting
Introduction: Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. Multiple studies have reported the epidemiology of this disease with conflicting results and limited sample size. Our aim is to further investigate the epidemiology of pancreatic cancer using a large database.
Methods: We used a commercial database (Explorys Inc, Cleveland, OH) which includes electronic health record data from 26 major integrated US healthcare systems. We identified all patients aged 18 and older who were diagnosed with pancreatic cancer, over the last 5 years based on Systematized Nomenclature Of Medicine – Clinical Terms (SNOMED-CT) and evaluated the prevalence of pancreatic cancer among all the patients in this database. We also performed univariate analysis to describe age-, race-, and gender-based distributions and to identify potential risk factors.
Results: Of the 36,728,450 individuals in the database, we identified 41,610 individuals with pancreatic cancer with an overall prevalence of 0.11%. Individuals with pancreatic cancer were more likely to be males, senior adults (age >65), Caucasians, (p< 0.0001 to all) compared to patients without pancreatic cancer. Similarly, patients with pancreatic cancer were more likely to have cystic fibrosis, viral hepatitis B and C, acute and chronic pancreatitis, diabetes mellitus type 1 and 2, (p< 0.0001 to all). Additionally, patients with pancreatic cancer were more likely to be smokers, drink alcohol, and take non-steroidal anti-inflammatory drugs (NSAIDs), (p< 0.0001 to all). Table 1 represents the odds ratio (OR) for all factors.
Discussion: This is one of the largest epidemiological studies investigating the prevalence and epidemiology of pancreatic cancer. Estimated prevalence rate of pancreatic cancer was 0.11%. Patients with pancreatic cancer were more likely to be males, senior adults (age >65), Caucasians, smokers, and take NSAIDs. They were also more likely to have Diabetes, Chronic pancreatitis, Hepatitis B, and Hepatitis C. Further studies are needed to confirm these findings.