Saad Saleem, MD1, Eric O. Then, MD2, Ahmad Abu-Heija, MD3, Simcha Weissman, DO4, Vinaya Gaduputi, MD, FACG2
1Mercy Health - St. Vincent Medical Center, Sylvania, OH; 2St. Barnabas Hospital, Bronx, NY; 3Wayne State University, Detroit Medical Center, Detroit, MI; 4Hackensack University - Palisades Medical Center, Teaneck, NJ
Introduction: Cannabis is the most frequently used illicit drug in the world. Increase use of marijuana had caused higher rates of cannabis-related adverse effects. This study aims to assess the cannabis use as an etiology of acute pancreatitis.
Methods: A retrospective analysis was conducted using the de-identified data from the national health database, the Healthcare Cost and Utilization Project (HCUP). We identified the hospital encounters for “cannabis use” using international classification of Diseases (ICD-9) diagnostic codes from 2011 to 2014. We assessed the incidence of acute pancreatitis in cannabis use patients and independent predictors of acute pancreatitis by multivariate analysis. P-values less than 0.05 indicated a statistically significant association. The odds ratio and 95% confidence interval were also calculated. Data were analyzed using SPSS.
Results: A total of 410385 cannabis use admissions were identified - 5469 (1.3%) acute pancreatitis with history of cannabis use (study group) and 404916 (98.7%) without acute pancreatitis in cannabis use population (control group). Comparing study group with control group, age - mean with standard deviation 39.8
+11.81 yrs vs. 36.09
+14.05 (P< 0.001) , sex - male 3901 (71.3%) vs. 252486 (62.4%) (P < 0.0001, Odds ratio [OR]= 1.50, Confidence interval (CI); 1.41-1.59), race - African American 1765 (32.3%) vs. 113524 (28%) (P< 0.0001, OR=1.22, CI; 1.15-1.30), smoking 3909 (71.5%) vs. 222558 (55%) (P< 0.0001, OR = 2.05, CI; 1.93-2.18), Alcohol 1959 (35.8%) vs. 54876 (13.6%) (P < 0.0001, OR = 3.56, CI; 3.37-3.77), acute pancreatitis 5469 (1.3%) vs. 4334 (0.7%) OR= 1.80 CI 1.73-1.87, P < 0.001).The odds of developing acute pancreatitis among cannabis use patient was significantly higher (P< 0.001, adjusted odds ratio [aOR]=1.20, CI; 1.14-1.25) (shown in Fig .1)
Discussion: This study showed that up to 20% increased likelihood of acute pancreatitis among the cannabis use patients. Older age, male sex, African American race, alcohol, smoking and cannabis use showed greater odds of developing acute pancreatitis.
Citation: Saad Saleem, MD; Eric O. Then, MD; Ahmad Abu-Heija, MD; Simcha Weissman, DO; Vinaya Gaduputi, MD, FACG. P0015 - ASSOCIATION BETWEEN ACUTE PANCREATITIS AND CANNABIS USE - A U.S. POPULATION-BASED STUDY. Program No. P0015. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.