Muhammad Talal Sarmini, MD1, Mohammad Maysara Asfari, MD2, Mohammad Alomari, MD1, Yasser Al-Khadra, MD1, George Khoudari, MD1, Srinivasan Dasarathy, MD1, Arthur J. McCullough, MD1
1Cleveland Clinic Foundation, Cleveland, OH; 2Medical College of Georgia at Augusta University, Augusta, GA
Introduction: Irritable bowel syndrome (IBS) and nonalcoholic fatty liver disease (NAFLD) are both very common gastroenterological disorders. There are recent reports in the literature linking these disorders together, but to date there are no large studies to highlight this relation. We aimed in this study to investigate whether IBS is an independent risk factor for NAFLD.
Methods: Using data from the National Inpatient Sample (NIS) database between 2003 and 2014, we identified patients who were diagnosed with IBS using appropriate ICD 9 coding. The control group was the patients who did not have a diagnosis of IBS. We then performed multivariate logistic regression analysis for the association between IBS and NAFLD.
Results: The total population was comprised of 84,456,866 patients, of which 637,942 (0.75%) were diagnosed with IBS. IBS patients were older (58 vs 57), more likely to female (82.7% vs 60.1%) and less likely to be African American (8.9% vs 14.8%) (P < 0.001 for all). In addition, IBS patients had less diabetes mellitus (DM) with or without complications (2.6% vs 3.8) and (13.7% vs 17%) respectively (P < 0.001). On the other hand, individuals in the IBS group had more obesity (11% vs 8.2%), hypertension (HTN) (47.6% vs 43.6%), hyperlipidemia (HLD) (20.6% vs 16%) (HLD) and hypothyroidism (16.5% vs 9.2%) (P < 0.001 for all). Using Multivariate logistic regression, and after adjusting for potential cofounding factors including (age, race, gender,obesity, HTN, HLD, DM and hypothyroidism), individuals in the IBS group had a statistically significant higher rate of NAFLD (Odds Ratio [OR], 3.204, 95% confidence interval [CI], 3.130 -3.279, P < 0.001) compared with the non-IBS group.
Discussion: In our study patients with IBS were three times more likely to have NAFLD. This finding supports the recent reports that suggest that the changes in gut microbiota, impaired intestinal permeability and impaired intestinal motility in IBS may also play an important role in NAFLD development.
Citation: Muhammad Talal Sarmini, MD; Mohammad Maysara Asfari, MD; Mohammad Alomari, MD; Yasser Al-Khadra, MD; George Khoudari, MD; Srinivasan Dasarathy, MD; Arthur J. McCullough, MD. P0347 - ASSESSING THE RELATION BETWEEN IRRITABLE BOWEL SYNDROME AND NONALCOHOLIC LIVER DISEASE. Program No. P0347. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.