Increasing evidence has shown that central venous pressure is not a reliable indicator of fluid status. Central venous pressure monitoring also requires the insertion of a central venous catheter, with complications such as pneumothorax, arrhythmias, bleeding, and nerve injuries. Stroke volume variation is a minimally-invasive, reliable, dynamic monitor of fluid status. Many studies have evaluated stroke volume variation monitoring as a guide for intra-operative fluid management. Stroke volume variation has also been evaluated as a method to reduce blood loss in liver resection. Overall the body of evidence supports the use of stroke volume variation monitoring in liver resection. Stroke volume variation can replace central venous pressure as a monitoring tool to guide fluid management. The use of a minimally invasive monitor to guide fluid management has the potential to reduce intra-operative risks for patients.