In planning the renovation of Smithsonian’s National Air and Space Museum, architects, engineers, and curators faced a number of technical design challenges shared by many other museums. Architectural features such as skylights and glass curtain walls introduce the need for daylight control, while the desire for winter humidification brings the risk of condensation. New glazing technologies are now available that allow for the active control of light levels. Modern 3D modeling methods allow the interaction of all these factors to be analyzed and the assessment of which modern technologies should be used in a particular situation. The understanding gained from such analyses can inform the designs of both new and renovated museum buildings.