Each one of the numbers in the 4-5-6 title has a meaning. The “4” is for the four (4) global diagnoses that dictate all interdisciplinary treatment planning. They are: 1) skeletal discrepancy, 2) short/hyperactive lip, 3) dentoalveolar extrusion, and 4) short teeth. The “5” is for the "5 core questions" that lead us through the diagnostic process to make a global diagnosis on any patient. The “6” is for the “6 tools” that we have as dentists to correct any landscape/tooth/gingiva discrepancy. This lecture will give an overview of the Global Diagnosis System and its use in treatment planning the complex interdisciplinary patient.