Mood Disorders

Neurobiology/Neuroscience

Psychopharmacology

The Role of Glutamatergic Signaling in MDD: Implications for Treatment-Resistant Depression

Saturday, October 27
9:15 AM - 10:30 AM
Location: Tangerine WF2

Glutamate is a poorly understood central nervous system (CNS) neurotransmitter that is emerging as a key therapeutic target in treatment-resistant depression (TRD). Multiple new compounds based on the glutamate mechanism of action are under investigation. Thus, clinicians urgently need a modern update on the neurobiology and functionality of glutamate and its clinical applications in TRD. This session will examine the physiology of glutamate synthesis, neurotransmission, mechanism of action, and its receptor pharmacology. New treatment options that work through the glutamate mechanism of action and how they fit into our treatment armamentarium for depression will also be reviewed.

Rakesh Jain, MD

Clinical Professor
Texas Tech
Texas Tech University School of Medicine - Permian Bason
Austin, Texas

Rakesh Jain, MD, MPH, attended medical school at the University of Calcutta in India. He then attended graduate school at the University of Texas School of Public Health in Houston, where he was awarded a “National Institute/Center for Disease Control Competitive Traineeship”. His research thesis focused on impact of substance abuse. He graduated from the School of Public Health in 1987 with a Masters of Public Health (MPH) degree.

Dr. Jain served a three-year residency in Psychiatry at the Department of Psychiatry and Behavioral Sciences at the University of Texas Medical School at Houston. He followed that by obtaining further specialty training, by undergoing a two-year fellowship in Child and Adolescent Psychiatry. In addition, Dr. Jain completed a postdoctoral fellowship in Research Psychiatry at the University of Texas Mental Sciences Institute, in Houston. He was awarded the “National Research Service Award” for the support of this postdoctoral fellowship.

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