To date, nearly every area of medicine uses biomarkers in some capacity to aid in understanding how personal biology informs clinical care. The NIH precision medicine initiative has propelled biomarkers research to the forefront of many translational research and care programs targeting specific disease based populations. Approaches by which to assess the utility of ‘omics research in the context of acquired disability is a relatively understudied area, yet precision care needs are important to consider as disability contributes an additional layer of potential biological impacts and factors which affect health and function. This session will overview recent advances in Rehabilomics research that is focused on linking personal biology to the biopsychosocial constructs that represent WHO-ICF model and multidimensional outcome for individuals with TBI. A roadmap for scaling and translating Rehabilomics research findings into precision rehabilitation care initiatives for individuals with TBI will be discussed.