Basic Science: Oncology
Moderated Poster Session
Introduction & Objective :
Surgical treatment of non-muscle-invasive bladder cancer (NMIBC) aims to completely remove all lesions as well as obtain a high quality specimen. Tumor grading and muscular invasion are the most important parameters influencing on treatment strategy and prognosis. Previous studies have shown that thulium en bloc resection of bladder tumors (ThERBT) provides a high quality specimen with the muscle layers in 96-100% of cases, while conventional transurethral resection of bladder tumors (cTURB) in only 50-86% of cases. Thulium laser allows to perform very precise resection of bladder wall layers with muscle fibers easily identified. Since the specimen is resected with surrounding mucosa during ThEBR, the horizontal surgical margin can be assessed. We looked at morphological characteristics of ThERBT and cTURB specimens.
26 patients with cT1 bladder cancer (16 - ThERBT group and 10 – cTURB group) were enrolled. The average tumor size was 17 mm (7 – 28 mm) and 15 mm (5 – 25 mm) in two groups respectively. ThERBT were performed with 1.94 µm thulium fiber laser Urolase (IRE-Polus, Russia), 1J x 10 Hz settings. Presence of muscle layer, the depth and extent of the lamina propria invasion, the depth of the specimen thermal damage were evaluated. Additionally, horizontal surgical margin was assessed.
Muscle layer was more often identified in the ThERBT group - 15 cases (94%) then in the cTURB group - 6 cases (60%), p<0.05. The lamina propria invasion was possible to assess in all ThERBT specimens and was detected in 13 cases (81%); in cTURB group only in 3 cases (30%) it was possible to evaluate the lamina propria invasion and in 2 of them it was found (p<0.05).The depth of thermal damage of specimens in ThERBT group did not exceed 1 mm in all cases, while in cTURB group it was on average 1.8 mm (1.0 – 3.0 mm), p<0.05. There was a rim of macroscopically intact mucosa around the tumor so the horizontal surgical margin was evaluated in all ThERBT specimens. The ability to assess the horizontal surgical margin in cTURB group was in 40%.
Specimens obtained with ThERBT are significantly provide more accurate information for staging compared with that obtained with cTURB due to less damage of tissue samples, enhanced ability to evaluate the lamina propria and muscle layer invasion. This allows to choose correct treatment strategy and avoid unnecessary second TURB.
RI for Uronephrology, Sechenov University
Deputy Director for Science
Institute for Urology and Reproductive health, Sechenov University
Deputy Director for Science, Institute for Urology and Reproductive health, Sechenov University
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