Laparoscopic/ Robotic: Prostate
Moderated Poster Session
MP18-18 - Is There a Relationship Between Phosphodiesterase Type 5 Inhibitors and Biochemical Recurrence After Radical Prostatectomy?
Saturday, September 22
10:00 AM - 12:00 PM
Location: Room 253
Qing He, MD
Department of Urology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan, 610041, P.R. China.
Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University
Department of Urology, West China Hospital, Sichuan University
Introduction & Objective :
To conduct a systematic review and meta-analysis of studies evaluating the association between PDE5I use and biochemical recurrence (BCR) after radical prostatectomy (RP).
We searched Embase (1996 to Feb 2018), PubMed (1996 to Feb 2018), and Cochrane library (1999 to Feb 2018) and supplemented by manual searches of reference lists of key retrieved articles. Original studies that reported risk of postoperative BCR for PDE5I users compared with non-PDE5I users were included. Data including the characteristic of participants, the risk of BCR after RP and key criteria of study quality. The pooled relative risks (RRs) were calculated with random-effects model.
A total of 5 cohort studies and 1 case-control study were identified for data analysis (a total of 17752 participants). Only 1 cohort study reported adjusted RR greater than 1 (range for all derived RRs, 0.7-1.47). The meta-analysis revealed the PDE5I users had no higher risk of BCR after RP (RR = 1.04, 95% confidence intercal [CI], 0.79-1.36). sensitivity analysis showed that the remained pooled RR and 95% CI were not changed significantly by omitting each study. In addition, the 5-year BCR rate had no significant difference between PDE5I users and non-PDE5I users.
Our meta-analysis indicated that PDE5I treatment in men following RP didn’t increase the risk of BCR. The results preliminarily suggested that PDE5I using for erectile dysfunction after RP was oncologically safe. Nevertheless, more large sample cohort studies are needed to validated this conclusion.