Clinical Oncology: Outcomes & Complications

Moderated Poster Session

MP23-3 - Factors Associated with Substantial Decline in Renal Function following Partial Nephrectomy

Saturday, September 22
2:00 PM - 4:00 PM
Location: Room 253

Introduction & Objective : To evaluate the factors that predict significant decline in renal function following partial nephrectomy (PN) at a minimum of 6 months follow-up.


Methods : Between May 2013 and November 2017, 323 patients underwent PN at Hackensack University Medical Center (HUMC). These patients were entered in an IRB – approved prospective/retrospective database. Inclusion criteria for this study included adherence to at least 6 months postoperative follow-up with a GFR measurement at that time. Univariate analysis was performed utilizing non-modifiable (age, sex, race, comorbid conditions, medications, pre-operative GFR, hematuria, proteinuria, tumor volume, tumor grade) and modifiable factors (operative time, ischemia time and type, mannitol administration, urine output, IV fluids, estimated blood loss) that are associated with the following outcomes at 6 months: decrease in GFR of over 25% (ΔGFR), downgrade in chronic kidney disease (CKD) stage (ΔStage) (Table 1).


Results : Eighty-one patients met inclusion criteria. We found a significant difference (p = 0.003) in age between patients who experienced ΔGFR and those who did not (69.0 vs. 58.7 years, respectively). There was a statistically significant difference (p = 0.046) in the percentage of patients with diabetes between patients who experienced ΔGFR than those who did not (40% vs 18%, respectively). For all other factors, there was no statistically significant difference between patients who experienced ΔGFR compared to those who did not. A summary of variables found to be significant predictors of ΔStage can be found in Table 2. We also found that patients with GFR <60ml/min were more likely to experience ΔStage than those that did not (OR: 5.8, p = 0.004).


Conclusions : We identified a number of factors that predict significant changes in renal function following PN. With an expanding prospective database, future studies should include multivariable analysis in the hopes of creating a predictive model.

Benjamin Press

Medical Student
Rutgers - New Jersey Medical School

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    Jessica A. Connor

    Medical student
    Rutgers - New Jersey Medical School

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      Saikrishnaraya Doppalapudi

      Medical Student
      Rutgers - New Jersey Medical School

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        Thaiphi Luu

        Medical Student
        Rutgers - New Jersey Medical School

        Thaiphi Luu, 4th year medical student, Rutgers New Jersey Medical School

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          Radhika Ragam

          Medical Student
          Rutgers - New Jersey Medical School

          Radhika Ragam, BS
          Medical Student - Rutgers New Jersey Medical School

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            Tenzin Lama-Tamang

            Hackensack University Medical Center

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              Helaine Koster

              Hackensack University Medical Center

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                John Stites

                Fellow, Endourology, Laparoscopy, Robotic Surgery
                Hackensack University Medical Center

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                  Mutahar Ahmed

                  Attending Urologist
                  Hackensack University Medical Center

                  Mutahar Ahmed MD FACS
                  Director of the Center for Bladder Cancer and Reconstructive Urologic Surgery at Hackensack University Medical Center, in Hackensack, NJ
                  Clinical Assitant Professor Hackensack Meridian Seton Hall School of Medicine
                  Clinical Assistant Professor Rutgers University School of Medicine

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                    Gregory Lovallo

                    Attending Urologist
                    Hackensack University Medical Center

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                      Ravi Munver

                      Professor & Vice Chair
                      Hackensack University Medical Center

                      Dr. Munver received his undergraduate education at Cornell University. He received his medical education at Cornell University Medical College and completed residency training in urologic surgery at Duke University Medical Center. He received fellowship training in robotic, laparoscopic, and endoscopic surgery at New York-Presbyterian Hospital/Weill Cornell Medical Center.

                      Dr. Munver is Vice Chair and Chief of Minimally Invasive and Robotic Urologic Surgery in the Department of Urology at Hackensack University Medical Center. He is a Professor of Urology at Hackensack Meridian School of Medicine at Seton Hall University and at Rutgers New Jersey Medical School. He is the founding Director of the Hackensack University Medical Center Endourology, Laparoscopy, and Robotic Surgery Fellowship Program.

                      Dr. Munver is a passionate academician and educator, and has lectured in 21 countries spanning 5 continents. He has authored more than 400 scientific manuscripts, articles, book chapters, and abstracts.

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                        Michael D. Stifelman

                        Chairman - Department of Urology
                        Hackensack University Medical Center

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