Category: Endoscopic

MP23-20 - Depth of invasion as a potential predictor of recurrence in patients treated with enblock-transurethral resection of the bladder: a feasibility study

Sat, Sep 22
2:00 PM - 4:00 PM

Introduction & Objective :

Background: As for other tumors it is likely that depth of invasion is a prognostic factor for disease recurrence and progression in high grade pT1 urothelial bladder cancer. To date nor anatomy based  neither dimensional subclassification proved reliable correlation with recurrence and progression, mainly considering the high interobserver variability in pT1 diagnosis, based by the TURB resection technique intrinsic artifact. 


Objective: Aim of this study is to assess the feasibility of measuring depth of invasion of urothelial carcinoma in patients undergoing EB-TURB for  pT1HG disease.


Methods :

Design, setting, and participants: 27 patients undergoing EB-TURB with Collins knife and with pT1-HG disease were included.  A second TURB was performed after 4-6 weeks from the first one. A dedicated pathologist assesses the feasibility of depth of invasion measurement


Outcome measurements and statistical analysis: evaluate depth of  invasion  using


Kruskal Wallis analysis and Chi-square test.


Results :

Results and limitations: Overall 32 patients with pT1HG disease were enrolled. EB-resection was adequately performed  in 27/32 (85%) of the patients. Overall 40 lesions were identified with a median tumour size of 2 cm (1/4).


Median depth of invasion was 1.35 mm (0.48/3.5). Deepness measurement was feasible in 100% of the patients and  in 100% of the lesions.  As well on re TURB 8/27(29%) patients presented residual disease and in 100% of these patients it was possible to measure depth of invasion with a median value was 1.1 mm (0.43/2.3). Limitations include number of patients.


Conclusions :


Conclusions:
In specimen obtained from EB-TURB measurement assessment proved to be easy and highly reproducible. Recruitment of patients is still ongoing to evaluate an eventual prognostic value of  neoplastic invasion in recurrence and progression.


Patient summary: In this report we want to find out if the thickness of invasion of urothelial carcinoma is related to tumor recurrence and progression measuring depth of invasion

Roberto Giulianelli

urology
Rome, Lazio, Italy

barbara cristina Gentile

urology
villa claudia
Rome, Lazio, Italy

Ludovica De vincentis

Rome, Lazio, Italy

Stefania Monclesi

Rome, Lazio, Italy

Gabriella Mirabile

Rome, Lazio, Italy

Luca Albanesi

Rome, Lazio, Italy

Paola Tariciotti

Rome, Lazio, Italy

Giorgia Tema

rOME, Lazio, Italy

Giorgio Rizzo

rome, Lazio, Italy

Pietro Aloisi

Rome, Lazio, Italy

Giuseppe Soda

Rome, Lazio, Italy