Category: Clinical Stones: PCNL

MP12-11 - A prospective, Randomized Trial evaluating the efficacy of two different Hemostatic sealant in Tubeless Percutaneous Nephrolithotomy

Fri, Sep 21
2:00 PM - 4:00 PM

Introduction & Objective : We performed a prospective, randomized trial to assess the safety and efficacy of Tisseel®, Tachosil® in tubeless percutaneous nephrolithotomy.


Methods :

A total of 75 patients undergoing tubeless percutaneous nephrolithotomy were randomized to receive Tisseel® (group 1), Tachosil® (group 2) and control (group 3) at the end of the procedure. The hemostatic sealants were placed under direct vision in the nephrostomy tract. The three groups were comparable in age, sex, height, weight, body mass index, stone size and in metabolic and anatomic features. Factors evaluated included postoperative blood loss, postoperative pain, hospital stay and perirenal hematoma formation.


Results : There was no difference in the hemoglobin, hematocrit decrease and blood transfusion requirements among the 3 groups. There was no significant difference in the extent of postoperative perirenal hematoma formation. (p=0.694) (Table 1) The average visual analog scale pain score on postoperative 1 day were 1.92±2.47, 1.72±1.67 and 1.48±1.73 respectively in each group. (p=0.378) The hospital stay were 2.28±0.93, 2.00±0.96, and 2.04±0.99 (p=0.579) in each group. No long-term sequelae were observed in the median follow up period of 24 months in any patient.


Conclusions : This study indicates that the hemostatic agents in standard tubeless PCNL were not expected to be effective or mandatory. Additional wide, prospective, randomized studies are required to get more fine clinical evidence for the hemostatic agent usage in tubeless PCNL.

Hyuk Jin Cho

Assistant Professor
Catholic University of Korea Seoul Saint Mary's Hospital
Seoul, Seoul-t'ukpyolsi, Republic of Korea

Kyu won Lee

Seoul, Seoul-t'ukpyolsi, Republic of Korea

Sae Woong Choi

Seoul, Seoul-t'ukpyolsi, Republic of Korea

Yong Sun Choi

Seoul, Seoul-t'ukpyolsi, Republic of Korea

Woong Jin Bae

Seoul, Seoul-t'ukpyolsi, Republic of Korea

Sung-hoo Hong

Seoul, Seoul-t'ukpyolsi, Republic of Korea

Ji Youl Lee

Seoul, Seoul-t'ukpyolsi, Republic of Korea

Sae Woong Kim

Seoul, Seoul-t'ukpyolsi, Republic of Korea

Kang Sup Kim

Clinical assistant professor
Department of Urology, Incheon St. Mary's Hospital The Catholic University of Korea, College of medicine
Incheon, Inch'on-jikhalsi, Republic of Korea

Kang Sup Kim (金 彊 燮), M.D., Ph.D

Clinical assistant professor
Department of Urology, Incheon St. Mary's Hospital
The Catholic University of Korea, College of medicine
59 Dongsu-ro, Bupyeong-gu, Incheon, Republic of Korea
Tel +82-32-280-5120 (Department office)

+82-32-280-5852 (Private office)
C.P. +82-10-3283-0876