Category: Imaging & Image Guided Therapy: New Therapies

MP4-5 - The relationship between PIRADSv2 scores and the incidence of prostate cancer in cognitive prostate biopsies

Fri, Sep 21
10:00 AM - 12:00 PM

Introduction & Objective : This preliminary study aims to investigate the relationship between PIRADSv2 score 3, 4 and 5 lesions in multiparametric prostate magnetic resonance imaging (mp-MRI) and histopathological outcomes of cognitivie systemic transrectal prostate biopsy (CSTPBx)

Methods : Between January 2017 - January 2018, 349 patients were imaged for prostate diseases using mp-MRI at radiology department. Amog them, 110 patients who underwent CSTPBx for PIRADSv2 score 3, 4 and 5 lesions in mp-MRI were included into this study. Clinical parameters, mp-MRI and CSTPBx findings were compared between three groups those were stratified by PIRADSv2 scores. Chi-square and Kruskal Wallis tests were used for the analyses of categorical and non-parametric continous variables. Bonferoni method z-test was used for post-hoc analysis of categorical variables.

Results : No difference was found between three groups in terms of age, clinical T stage and prostate volume meanwhile PSA (5.2 vs. 5.8 vs. 13 ng/ml, p=0.006) and PSA density (0.14 vs. 0.13 vs. 0.22 ng/ml/cc, p=0.017) were significantly higher in PIRADS 5 group. The proportion of benign prostate hyperplasia (BPH), premalign lesion and prostate cancer (Pca) were similar between three groups. Despite a lack of statistical significance, a tendency of increased Pca rate in higher PIRADSv2 scores was notable (26.1 vs. 51.4 vs. 58.8 %, p=0.215). The Bonferoni z-test showed that the proportion of high risk Pca in PIRADS 5 score is significantly higher than PIRADS 3 and 4 scores (0 vs. 13.9 vs. 70 %, p<0.001)

Conclusions : This preliminary study suggested that Pca diagnosis tended to be higher in parallel with increasing PIRADSv2 scores and PIRADSv2 score 5 lesion was significantly associated with more aggressive and high risk prostate cancer.           

Selcuk Erdem

Academic Staff (Urologist)
Department of Urology Istanbul University, Istanbul Faculty of Medicine
Fatih, Istanbul, Turkey

Selcuk Erdem, MD, Fellow of European Board of Urology (FEBU)
Department of Urology, Istanbul University Istanbul Faculty of Medicine

Faruk Ozcan

Istanbul, Istanbul, Turkey

Yasin Yitgin

Istanbul, Istanbul, Turkey

Samed Verep

Istanbul, Istanbul, Turkey

Baris Aydin

Istanbul, Istanbul, Turkey

Atadan Tunaci

Istanbul, Istanbul, Turkey

Haluk Ander

Istanbul, Istanbul, Turkey

Oner Sanlı

Fatih, Istanbul, Turkey