Category: Basic Science: Stones

MP2-18 - Ethanolic Extract of Cotinus coggygria Leaves Attenuate Crystalluria and Kidney Damage in Ethylene Glycol Induced Urolithiasis in Rats

Thu, Sep 20
4:00 PM - 6:00 PM

Introduction & Objective : Cotinus coggygria L. is used in Turkish folk medicine as a remedy for a wide range of ailments (1). The aim of the present study was to investigate the preventive and curative effects of Cotinus coggygria extract in ethylene glycol (EG) induced urolithiasis model in rats. 

Methods : 32 Wistar albino rats were randomly divided into Control, EG, Preventive and Curative groups. EG (0.75%) was added into drinking water to develop urolithiasis model. Control group received drinking water for 8 weeks. EG group received EG (0.75%) and Preventive group received both EG and Cotinus coggygria extract for 8 weeks. In Curative group, EG (0.75%) was given for 8 weeks where the extract was received during last 4 weeks. At the end of the experiment, 24-hours urine was collected and after decapitation, kidney tissue samples were obtained.

Results : Urinary ion levels (calcium, citrate) and creatinine were diminished in both preventive and curative groups. Oxalate levels were increased in EG group, while those were maintained at control levels in preventive group and reverted back to control levels in curative group. Furthermore the increased N-acetyl-β-glucosaminidase and myeloperoxidase activities in EG group, were significantly reversed with Cotinus coggygria treatment. 

Conclusions :

Our results support that Cotinus coggygria extract can lower urinary concentration of stone-forming constituents thereby can protect kidney tissue damage. Thus it may be considered as a potential prophylaxis and treatment agent option in patients who have high risk of forming urinary stones.

1. Sener TE, Sener G, Cevik O, Eker P, Cetinel S, Traxer O, Tanidir Y, Akbal C. The Effects of Melatonin on Ethylene Glycol-Induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression. Urology, 99:287. e9-287.e15.  2. Thamilselvan S, Hackett RL, Khan SR. Lipid peroxidation in ethylene glycol induced hyperoxaluria and calcium oxalate nephrolithiasis. The Journal of urology. 1997;157: 1059-1063.  

Tarık Emre Sener

Marmara University, Department of Urology, Istanbul, Turkey
Istanbul, Istanbul, Turkey

Tarik Emre SENER, MD, FEBU
Marmara University, School of Medicine
Department of Urology
Istanbul / Turkey

Tarik Emre Sener, after graduating from French high school Lycée Saint-Joseph, Istanbul, studied Medicine between the years 2004-2010 in Marmara University, School of Medicine in Istanbul. He completed his residency training in Urology between the years 2011-2016 in Marmara University, School of Medicine, Department of Urology. During his residency, he completed 3 months of Endourology Fellowship in Tenon University Hospital, Paris alongside Professor Olivier Traxer. During his medical and residency training, he has presented several abstracts at international meetings and has authored many peer-reviewed articles covering a broad range of topics in Endourology, Pediatric Urology, Pharmacology and Physiology.
He is currently working in Marmara University, School of Medicine, where he is involved in all the medical and surgical management of patients as well as many scientific research projects.
He is the founder member and current general secretary of PETRA Urogroup, an international collaboration group dedicated to scientific and surgical activities on Endourology and Stone Diseases.

Address: Acıbadem Mahallesi Çeçen Sokak, Almondhill Konutları B8 blok Daire:6 Üsküdar İstanbul Türkiye 34660
Contact Information:
Cellular: +90 533 762 07 12
Twitter: @dremresener

PETRA Urogroup Website:
Link to Research Gate:

Busra Ertas

Istanbul, Istanbul, Turkey

Ali Sen

Istanbul, Istanbul, Turkey

Pınar Eker

Istanbul, Istanbul, Turkey

Goksel Sener

Professor of Pharmacology
Marmara University, School of Pharmacy
Istanbul, Istanbul, Turkey

NAME SURNAME: Goksel Sener
OFFICE ADDRESS: Marmara University School of Pharmacy, Department of Pharmacology, Haydarpasa 34668 – ISTANBUL
Tel: 90216-4142962 Fax: 90216-3452952

EDUCATION: 1987-1994: Marmara University, Ph.D in Pharmacology
2002-2007: Associate Professor of Pharmacology
2007-. : Professor of Pharmacology

- animal models of kidney stone formation
-Ulcer and colitis pathogenesis
-Inflammatory processes (sepsis, thermal trauma, ischemia/reperfusion, etc.), free radicals and antioxidants
-Cardiovascular system
-Oxidative stress
-Free radicals and antioxidants

PUBLICATIONS: Prof. Sener has more than 200 published articles.