Exhibitor Tutorial

A new software solution for scalable and streamlined processing of high-throughput data from mechanistic screening

Tuesday, February 6
9:30 AM - 10:15 AM
Location: Room 5A

Early inclusion of mechanistic information is key for modern drug programs. Kinetic information in particular can dramatically increase the yield and speed up the propagation of high quality lead candidates. This tutorial will introduce a new software solution developed in close collaboration with a major pharma company, which ensures consistent and reliable processing of biophysical and/or mechanistic assays in scalable high throughput.
Examples of supported assay formats are Mechanism of Inhibition, Progress Curves (Slow binding/Jump dilution), and kinetic Probe Competition Assays (kPCA). We highlight the main achievement of the solution: fast and consistent availability of all mechanistic screening result parameters on a corporate level, at the detail required for any downstream consumption. Key visualizations and quality control tools are briefly introduced before we illustrate from an enterprise perspective how this software can be streamlined into a modern pharma research workflow, reliably delivering high-quality result parameters at the speed required in today’s programs.

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Stephan Steigele

Head of Science
Genedata AG

Dr. Stephan Steigele received his Dipl. Biol. from the the University of Hohenheim, Germany (main focus in neurophysiology / biochemistry / genetics) and his Dr. rer. nat. (PhD) from the computer science department at the University of Leipzig, Germany; followed by a postdoc position in RNA/protein informatics and comparative genomics at the same university and at Fraunhofer Institute for Cell Therapy and Immunology (IZI).

He works for Genedata since 2009; He is an initiator and leader on various projects, e.g. for enabling complex technologies (APC, Label-Free, HCS, DMPK, TSA, SPR) with a recent focus on Deep Learning and Machine Learning and their application in pharma relevant areas; for prototyping and formulating production ready solutions.

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A new software solution for scalable and streamlined processing of high-throughput data from mechanistic screening



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