Alex Aronov
Director, Data Strategy and Solutions
Vertex Pharmaceuticals Inc.
Presentation(s):
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Evolution of Small Molecule Screening Libraries
Wednesday, February 7
10:30 AM – 11:00 AM
Chemical Biology
Evolution of Small Molecule Screening Libraries
Wednesday, February 7
10:30 AM - 11:00 AM
Location: 8
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Alex Aronov, PhD, MBA
Director, Data Strategy and Solutions
Vertex Pharmaceuticals Inc.
The past decade has seen an evolution in our approaches to both the content of the small molecule screening collections and the ways to optimally use the established libraries. The talk will address a number of facets of screening deck assembly and utilization: size and organization of the HTS screening deck; dynamic hit forecasting; identification and removal of frequent hitters; expanding HTS deck with new chemical matter; successful application of fragment libraries; and assembly and stewardship of chemogenomic libraries.