Short Courses

Applications of Biophysical Methods in Small-Molecule Drug Discovery

• 

  Christine Genick, Dr.

  Lab Head/ Investigator II
  Novartis
• GH

  Geoff Holdgate

The course will be delivered in two parts; the first section will focus on the theoretical aspects of each biophysical method in a seminar format and in the following section their practical applications will be brought to light in an open and active discussion format. For the first section, you will receive a series of brief high-level presentations concerning the biophysical theory behind each technology and their application in lead finding, hit validation as well as more in depth mechanistic studies. This will enable you to gain a rapid overview of the most relevant biophysics/ label-free technologies for screening and lead finding/characterization. In the second section you will be presented with some challenges on how to effectively apply those technologies by looking at a range of common scenarios from different phases of lead discovery. This will include fragment-based drug discovery, hit validation and confirmation, in-depth hit characterization and support of HTS assay development. Making use of an active and open discussion forum, you, as a part of a team, will thereby gain further insight about the usage, impact, and limitations of each biophysical technology.

Additional fees apply. Visit http://www.slas2018.org/program/short-course-program/ for more information.