Data Analysis and Informatics

Automating Screening Cascades: Linking Compound Data to Compound Logistics

Monday, February 5
12:00 PM - 12:30 PM
Location: 8

Plate-based assays are often part of a series of assays designed to narrow down a list of compounds and/or gain knowledge regarding selectivity, on/off target effects, ADME mechanisms, or pharmacological profile. This presentation will demonstrate the concept of Automated Screening Cascades (ASCs) that integrate the decision making algorithm with compound logistics. ASCs automatically identify and submit compounds to the next assay in the cascade. This ensures that no compounds and data are missed. Data processing tools can be built to enable users to ‘subscribe’ Discovery Projects to a collection of logically linked assays such that any compound made for that Project is automatically selected, submitted, and processed for screening with minimal end user input. In automating the compound selection process, compounds can go through the defined screening funnel efficiently and effectively to minimize cycle times and speed up the decision making process.

Travis Mathewson

Senior Principal Scientist
Pfizer Inc

I'm currently a Senior Principal Scientist at Pfizer in Groton Connecticut who currently manages the Automation and Data Support group within the Compound Management & Distribution Group, which delivers continuous improvement solutions for automated sample management workflows. This includes: plate registration and compound layout support, plate and compound inventory, workflow and metrics tracking, data curation, automated instrument monitoring, instrument quality control, troubleshooting, and custom solutions to support Lead Development, Hit Identification, and Sample integrity workflows. I started my career with Pfizer in 1995 in high-throughput screening (HTS). In addition, I've managed the Pfizer HTS screening compound collection and helped to build automated screening workflows. In collaboration with Evotec from 2001 to 2006, I applied innovative nanoliter technology in high density 1,536 and 2,080 well plates to enable ultra-high through-put screening (uHTS) in single microliter or less total assay screening volumes and contributed to the innovative nanostore concept.

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