Category: Assay Development and Screening

1371-B - Smart Chemical Libraries from Prestwick Chemical: Powerful tools for high-quality hit discovery

Monday, February 5, 2018
5:00 PM - 6:00 PM

Smart Chemical Libraries from Prestwick Chemical:


Powerful tools for high-quality hit discovery


 


 


Liliane Soares,1 Jean-Marie Contreras,1 Laurent Schaeffer,1 Christophe Morice,1 Laurence Jung,1 Jean-Marc Simon,1 Marie-Louise Jung,1 and Bruno Didier2



  1. Prestwick Chemical, 220 Blvd Gonthier d'Andernach, 67400 Illkirch, FRANCE

  2. University of Strasbourg, Therapeuthic Innovation Laboratory, UMR7200 CNRS, Faculty of Pharmacy, 74 route du Rhin, 67400 Illkirch, FRANCE


 


Despite all current efforts dispensed in drug discovery, safety-related problems continue to be one of the major causes for drug attrition in preclinical and clinical development. In order to circumvent this concern, toxicity issues should be considered as early as possible and smart chemical libraries be privileged for screening. Therefore this poster will present the features of three smart chemical libraries – the Prestwick Chemical Library® (PCL), the Prestwick CNS Drug Library and the Prestwick Drug-Fragment Library –. Designed to ensure high-quality hits and therefore reduce cost of the initial screening, they can be considered as powerful tools for hit discovery. The PCL is a product arising from medicinal chemistry expertise, comprising 1280 off-patent drugs, thus presenting a large degree of chemical and pharmacological diversity within a relatively small number of compounds. The Prestwick CNS Drug Library is a unique collection of 320 structurally diverse approved and marketed drugs carefully selected for their known pharmacological effects on the central nervous system. The Prestwick Drug-Fragment Library is a collection of 2000 fragments arising from the smart fragmentation of the PCL approved drugs. The fragmentation process was performed manually, based on our expertise in medicinal chemistry.


Over the 16 past years, “hit-likeness” and “hit-workability” of our smart chemical libraries have been substantially reported by users.

Liliane Soares

Sales Manager North America
Prestwick Chemical
San Diego, CA

Liliane Soares is the Sales Manager North America at Prestwick Chemical SAS. Her responsibilities includes developing and implementing new strategies and products in collaboration with the Head of Screening Libraries department. Her background is in Biochemistry and Organic chemistry. www.linkedin.com/in/liliane-soares-sd16