Category: Automation and High-Throughput Technologies

1108-D - Development of an Automated Workflow for High-Throughput Screening of Nanocrystal Suspension Formulations

Tuesday, February 6, 2018
5:00 PM - 6:00 PM

Formulating low solubility compounds as nanocrystal suspensions can improve in vivo dissolution and bioavailability. This enabling formulation technology has been used in several commercial drug products for different routes of administration including oral, IV, and inhalation. A highly-automated nanocrystal suspension formulation screening workflow utilizing an in-situ milling technique has been designed to decrease the resources,  time, and effort typically invested in developing and selecting a suitable nano formulation. The resulting formulations are characterized by milling efficiency at multiple milling time points, particle size distribution, and physicochemical stability. This workflow not only allows for evaluating numerous formulation compositions in 96-well plate format using minimal API material, but is also well-suited to formulation scale-up in  for in vivo dose administration.  

Stephanie Azali

Senior Associate
Amgen
Newbury Park, California

Received BS in Chemistry from Pepperdine University in 2010 and began working in R&D at Amgen in Fall of 2010.