Category: Automation and High-Throughput Technologies

1093-D - High throughput spectroscopy for process analysis with quantum cascade laser frequency combs

Tuesday, February 6, 2018
5:00 PM - 6:00 PM

High-speed spectroscopy for process analysis

High-speed vibrational spectroscopy is an important tool for understanding biological processes, chemical reaction pathways and process analysis in general. Speed combined with high selectivity and sensitivity are key drivers for next generation process analysis tools.

We present the IRspectrometer, a quantum cascade laser dual frequency comb spectrometer. It allows for parallel acquisition of hundreds of mid-infrared wavelengths at microsecond time resolution. Recently, we performed proof of principle measurement of the light induced reaction of Bacteriorhodopsin. The reaction has been recorded that show the infrared response of bacteriorhodopsin to 10 ns visible light pulses with microsecond time-resolution. The different wavelengths were all measured in parallel thanks to the dual-comb approach.

This time-resolved measurement proofs the extremely high sensitivity and selectivity at high speed of the IRspectrometer. Enzyme kinetics can be measured and fast screening processes, where speed and reliable identification of substances is key, will be revolutionized.

Markus Mangold

Staefa, Switzerland

Throughout my academic career I have been concerned with opto-electronic properties of materials and their application. As a postdoc, I have been acquainted with mid-infrared absorption spectroscopy for environmental applications. With IRsweep, I can leverage on this expertise to make novel, frequency-comb spectroscopy available to researchers in the world.