Category: Assay Development and Screening
Surface tension is a key factor to determine the liquid distribution in small vessels under orbital mixing conditions. Although of interest for a range of industrial applications, currently no practically applicable model that describes this relationship is available.
In the present study the liquid motion in small microplate wells under orbital mixing conditions is explored theoretically and experimentally. A mathematical model was developed to predict the liquid distribution in the vessel depending on operating conditions, geometry and physical parameters. The equations of the model are based on the non-linear differential equations which are describing the axisymmetric rotation of a liquid in consideration of the surface tension.
The developed computational model was examined against different cases of liquid distribution. As a result, the model enables a time efficient way to determine optimal operation conditions in particular mixing speed and orbital radius based on the correlation between physical properties, geometric parameters and filling volume.
The developed mathematical model was validated based on experimental results of studies conducted with orbital shakers of the BioShake series.
Olaf Simmat– CEO, Quantifoil Instruments GmbH, Jena, Thuringen, Germany
Quantifoil Instruments GmbH
Jena, Thuringen, Germany
I'm passionate to reinvent Life Science for the future age.
In 2003, I set out with a simple vision: Equip every laboratory with brilliant shakers and make sample preparation a valued experience again.
Now, the patended BioShake innovations & design define the global shaker standard in terms of compactness, speed, quietness, and precision.
I am always searching for new ideas and improvement possibilities for biomedical applications.
CEO of QInstruments, GERMANY