Category: Micro- and Nanotechnologies

1038-D - Development and characterization of hyaluronic acid/nano-Gold/chitosan modified carbon nanomaterial hydrogel composite

Tuesday, February 6, 2018
5:00 PM - 6:00 PM

Carbon nanomaterial – hydrogel composites are attractive for the widely used in biomedical applications such as tissue engineering, drug delivery and biosensor coatings. Hydrogels that obtain from natural polysaccharide can be ideal scaffolds for tissue regeneration due to the fact that their constitutions is similar with the extracellular matrix of tissues which are made up of different kinds of glycosaminoglycans, biocompatibility, hydrophilicity and viscoelasticity, especially Hyaluronate (HA) and Chitosan. Here we demonstrate that the development of a novel hydrogel composite which was combined with biopolymers, gold nanoparticles and carbon nanomaterials for optimizing the mechanical and chemical properties of hydrogels. The gelation attribute to the Schiff base reaction between the aldehyde groups on oxidized HA and the amine groups on Chitosan. To ensure the materials were fully cross-linked, the cross linker, adipic acid (ADH), was introduced in order to enhance the whole structure. The microstructure, compressive modulus, and degradation time of hydrogel composites were determined. The results presented that the hydrogel composites exhibited low toxicity and provided compelling properties of them. These features gave the hydrogel composites a potential opportunity as a biomaterial on tissue engineering applications.

KEUN-CHAN LEE

Assistant Professor
National Taipei University of Education
Taipei, Taipei, Taiwan (Republic of China)

Professor Lee received his DPhil degree from the University of Oxford, UK. Then he moved to CalTech, USA for pursuing his postdoctoral training. He is currently working at National Taipei University of Education, and the main focus of his laboratory is in developing Material Chemistry for Nanomedicine and Drug Delivery applications.