Category: Micro- and Nanotechnologies

1011-B - A swellable microneedle patch to rapidly extract skin interstitial fluid for timely metabolic analysis

Monday, February 5, 2018
5:00 PM - 6:00 PM

Skin interstitial fluid (ISF) is an emerging source of biomarkers for disease diagnosis and prognosis. Microneedle (MN) patches have
been identified as an ideal platform to extract ISF from the skin due to their pain-free and easy-to-administrated properties. However,
long sampling time is still a major challenge that inhibits timely metabolic analysis. This study develops a swellable MN patch that
can rapidly extract ISF in minutes. The MN patch is made of methacrylated hyaluronic acid (MeHA) and further crosslinked through
UV. Owing to the supreme water-affinity of MeHA, this MN patch can extract sufficient ISF in a few minutes without the assistance
of extra device. The covalent crosslinked network retains the structure integrity of MNs in the swelling hydrated state. More
importantly, the extracted ISF metabolites can be efficiently recovered from MN patch using centrifugation for the subsequent off-line
analysis of metabolites like glucose and cholesterol. Given the recent trend of easy-to-use point-of-care devices for personal
healthcare monitoring, this work will open a new avenue for the development of MN-based microdevices for sampling ISF and
minimally-invasive metabolic detection.

Chenjie Xu

Assistant Professor of Bioengineering
Nanyang Technological University
Singapore, Not Applicable, Singapore

Dr. Chenjie Xu is an assistant Professor at Nanyang Technological University, Singapore. He is interested in the biomedical
applications of nanotechnology. Specifically, his current research focuses on the development of nanoparticles and microneedles
for transdermal drug delivery and biosensing.